Tadalafil - API Active Pharmaceutical Ingredient

Tadalafil

Name	Tadalafil
Synonyms	(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione CIALIS IC 351 TADALAFIL TADALAFIL(CIALIS) Taladafil (cialis) Cialis/taladafil Cialis(IC351) Tadanafil TADALAFIL 99 % TADALAFIL (CIALIS,USP) CIALIS/TADALAFIL (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Tadalafei GF 196960 ICOS 351 Tildenafil UK 336017
CAS NO	171596-29-5
Molecular Weight	389.4
EINECS	687-782-2
Molecular Formula	C22H19N3O4
Product Categories	11; Steroid and Hormone; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's; NUCYNTA; API; Tadalafil; Inhibitor; Pyridines,Halogenated Heterocycles; Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction
Mol File	171596-29-5.mol

Tadalafil Chemical Properties
Melting point	298-300°C
Boiling point	679.1±55.0 °C(Predicted)
alpha	D20 +71.0°
density	1.51±0.1 g/cm3(Predicted)
form	powder
Fp	2℃
solubility	DMSO: soluble20mg/mL, clear
color	white to beige
optical activity	[α]/D +68 to +78°, c = 1 in chloroform-d
InChIKey	WOXKDUGGOYFFRN-IIBYNOLFSA-N
pka	16.68±0.40(Predicted)
storage temp.	Hygroscopic, -20?C Freezer, Under Inert Atmosphere
CAS DataBase Reference	171596-29-5(CAS DataBase Reference)

Safety Information
Hazard Codes	F,Xn
Risk Statements	11-20/21/22-36
Safety Statements	16-36/37
WGK Germany	3
RTECS	UQ4431050
HS Code	2934990002
Hazardous Substances Data	171596-29-5(Hazardous Substances Data)

Tadalafil Usage And Synthesis
Indications and uses	Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Clinical Research	In a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.
Side effects	No severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.
Warnings and precautions	igestion. Warnings and precautions Patients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.
Description	Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.
Chemical Properties	White to Off-White Cyrstalline Solid
Originator	Lilly/ICOS (US)
Uses	analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist
Definition	ChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR

Package method

包装材料.jpg

FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.

Shipment: By express to buyers’ door. 100% make sure delivery.

Payment: TT/ Western Union/BTC/ETV/VISA and so on, please contact by email.

Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost

CATALOG

Steroid/Hormone Raw Materials

Finsihed Steroid/Hormone/Peptides