Avanafil - API Active Pharmaceutical Ingredient

Avanafil

Name	Avanafil
Synonyms	4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide; 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil PDE5 inhibitor;vanafil; (S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; avanfil; (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl
CAS NO	330784-47-9
Molecular Weight	483.95
Molecular Formula	C23H26ClN7O3
Product Categories	Avanafil;Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals;API;Aromatics;Chiral Reagents;Heterocycles;Inhibitors
Mol File	330784-47-9.mol

Avanafil Chemical Properties
Melting point	150-152°C
density	1.372
pka	11.84±0.46(Predicted)
storage temp.	Refrigerator
CAS DataBase Reference	330784-47-9(CAS DataBase Reference)

Safety Information
HS Code	29339900

Safety Information

HS Code

29339900

Avanafil Usage And Synthesis
Description	Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.
Chemical Properties	White Solid
Originator	Mitsubishi Tanabe Pharma Corporation (Japan)
Uses	Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM
Uses	A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.
Definition	ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid with the amino group of pyrimidin-2-ylmethylamine Used for treatment of erectile dysfunction.

Package method

包装材料.jpg

FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.

Shipment: By express to buyers’ door. 100% make sure delivery.

Payment: TT/ Western Union/BTC/ETV/VISA and so on, please contact by email.

Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost.

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