Mesterolone - API Active Pharmaceutical Ingredient

Mesterolone

Name	Mesterolone
Synonyms	17beta-hydroxy-1alpha-methyl-5alpha-androstan-3-one 1ALPHA-METHYLANDROSTAN-17BETA-OL-3-ONE 5-ALPHA-ANDROSTAN-1-ALPHA-METHYL-17-BETA-OL-3-ONE MESTERELONE MESTERLONE MESTEROLONE 17-beta-hydroxy-1-alpha-methyl-5-alpha-androstan-3-on 17-hydroxy-1-methyl-,(1-alpha,5-alpha,17-beta)-androstan-3-on 1-alpha-methyl-17-beta-hydroxy-5-alpha-androstan-3-one 1-alpha-methyl-5-alpha-androstan-17-beta-ol-3-one androviron mesteranum mesterolon mesterolone--deascheduleiii mestoranum proviron sh723 testiwop mesterolone standard solution MesteroloneAcetateBase
CAS NO	1424-00-6
EINECS	215-836-3
Molecular Weight	304.47
Molecular Formula	C20H32O2
Product Categories	API; Steroid and Hormone; Biochemistry; Hydroxyketosteroids; Steroids
Mol File	1424-00-6.mol

Mesterolone Chemical Properties
Melting point	208 °C
alpha	D20 +17.6° (c = 0.875 in CHCl3)
Boiling point	420.3±45.0 °C(Predicted)
density	1.156 g/cm3
refractive index	17.6 ° (C=0.9, CHCl3)
storage temp.	2-8°C
solubility	Practically insoluble in water, sparingly soluble in acetone, in ethyl acetate and in methanol
form	neat
pka	15.09±0.70(Predicted)
Merck	5916
InChIKey	UXYRZJKIQKRJCF-TZPFWLJSSA-N
CAS DataBase Reference	1424-00-6(CAS DataBase Reference)

Mesterolone Usage And Synthesis
Chemical Properties	White or yellowish crystalline powder
Originator	Proviron,Schering,W. Germany,1967
Uses	Mesterolone is a synthetic androgen and a dihydrotestosterone derivative. Mesterolone is rarely used for replacement therapies due to its weak androgenic activity.
Manufacturing Process	500 mg of 1α-methyl-androstan-17β-ol-3-one-17-acetate are heated under reflux for 90 minutes in a nitrogen atmosphere in 5 ml of 4% methanolic sodium hydroxide solution. The reaction mixture is then stirred into ice water,the precipitated product filtered with suction and recrystallized from isopropyl ether. 1α-Methyl-androstan-17β-ol-3-one melts at 203.5° to 205°C.
Therapeutic Function	Androgen