Allylestrenol - API Active Pharmaceutical Ingredient

Allylestrenol

Name	Allylestrenol
Synonyms	13-methyl-17-prop-2-enyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol 4-ESTREN-17-ALPHA-ALLYL-17-BETA-OL ALLYLESTRENOL 17-allyl-estr-4-en-17-beta-o 17-allylestr-4-en-17-beta-ol 17-alpha-allyl-17-beta-hydroxy-4-estrene 17-alpha-allyl-17-beta-hydroxy-delta(sup4)-estren 17-alpha-allyl-3-deoxy-19-nortestosterone 17-alpha-allyl-4-estren-17-beta-ol 17-alpha-allyl-4-oestrene-17-beta-ol 17-alpha-allylestr-4-en-17-beta-ol 17-alpha-allylhydroxy-19-nor-4-androstene 17-hydroxy-17-alpha-allyl-4-estrene 21-methylene-19-nor-17-alpha-preg-4-en-17-o 21-methylene-19-nor-17-alpha-preg-4-en-17-ol 3-deoxy-17-alpha-allyl-19-nortestosterone allyl-estreno allyloestrenol gestanin gestanol
CAS NO	432-60-0
EINECS	207-082-9
Molecular Weight	300.48
Molecular Formula	C21H32O
Product Categories	Steroid and Hormone; Inhibitors; Medicine intermediate
Mol File	432-60-0.mol

Allylestrenol Chemical Properties
density	0.9914 (rough estimate)
Boiling point	381.7°C (rough estimate)
Melting point	79.5-80°
refractive index	1.4800 (estimate)
pka	14.95±0.40(Predicted)
CAS DataBase Reference	432-60-0(CAS DataBase Reference)
Merck	14,291

Safety Information
RTECS	KG7960000

Allylestrenol Usage And Synthesis
Originator	Alilestrenol ,Terapia
Uses	A synthetic steroid with progestational activity.
Manufacturing Process	To 145 ml of dry methylamine which is cooled to -20°C 1.5 g of lithium cut to small pieces are added. To the solution which is blue in color after 10-20 min, a solution of 3.0 g of oestradiol-3-methylether in 145 ml of absolute ether is added drop wise. Subsequently the reaction mixture is stirred at -10°C for 40 h, after which 50 ml of absolute ethanol are added. Then the methylamine is distilled off at law pressure. To the remaining solution 50 ml of ether and 50 ml of water are added. The water layer is separated and extracted with ether. The ethereal layer is washed with a 2 N hydrochloric acid solution, subsequently with a saturated sodium bicarbonate solution, and then with water. The ethereal solution is dried and evaporated to dryness. The resulting crude reaction product is dissolved in a mixture of benzene and petroleum ether (1:3) and chromatographed over aluminium oxide. The δ4-17β-hydroxy-oestrene obtained after chromatographic purification has a melting point of 80°-90°C and 95°-100°C after repeated crystallization from petroleum ether. A solution of 13.2 g of chromium trioxide in a mixture of 120 ml of water and 20 ml of acetic acid is added, with stirring, to a solution of 20 g of δ4-17β- hydroxy-oestrene in 400 ml of benzene. Subsequently the reaction mixture is vigorously stirred at room temperature for 16 h, after which the benzene layer is separated. The remaining aqueous layer is extracted a few times with benzene and the benzene extracts collected are then added to the separated benzene layer. The benzene extracts are successively washed with dilute sulfuric acid and water and then evaporated to dryness. The residue is crystallized from acetone, and the δ4-17β-oxo-oestrene, melting point 114°-116°C is obtained. To a mixture of 22.4 ml of absolute ether and 1.84 g of magnesium, a mixture of 2.72 ml of allyl bromide and 2.72 ml of absolute ether is added in nitrogen atmosphere. Subsequently a solution of 2 g of δ4-17β-oxo-oestrene in 30 ml of absolute ether is added to this reaction mixture, after which the whole is stirred for 4 h. Then the reaction mixture is poured into acidified ice water. The aqueous mixture is extracted with ether; the ether layer is separated, washed with water, dried over sodium sulfate and evaporated to dryness. The residue is recrystallized from a mixture of ether and petroleum ether, giving δ4-17β-hydroxy-17α-allyl-oestrene, melting point 79.5°-80°C.
Therapeutic Function	Progestin; Antiandrogen

Allylestrenol Preparation Products And Raw materials
Raw materials	Lithium-->Magnesium-->Acetic acid-->Allyl bromide-->Chromium(VI) oxide-->Methylamine

Allylestrenol Preparation Products And Raw materials

Raw materials

Lithium-->Magnesium-->Acetic acid-->Allyl bromide-->Chromium(VI) oxide-->Methylamine

Package method

包装材料.jpg

FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.

Shipment: By express to buyers’ door. 100% make sure delivery.

Payment: TT/ Western Union/BTC/ETV/VISA and so on, please contact by email.

Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost.

CATALOG

Steroid/Hormone Raw Materials

Finsihed Steroid/Hormone/Peptides