| Name | Hydrocortisone Acetate |
|---|---|
| Synonyms | (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione; 11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate; 11-beta,17-alpha-dihydroxy-21-acetoxypregesterone; 11beta17alpha-Dihydroxy-21-acetoxypregesterone; 17-alpha-hydrocorticosterone21-acetate; 17alpha-Hydrocorticosterone-21-acetate;Cortisone Acetate EP Impurity A（Hydrocortisone Acetate）; Hydrocortisone Impurity 3（Hydrocortisone EP Impurity C） 11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-ACETATE 17-ALPHA-HYDROXYCORTICOSTERONE ACETATE 17-HYDROXYCORTICOSTERONE 21-ACETATE 17-HYDROXYCORTICOSTERONE ACETATE 21-acetoxy-4-pregnene-11b,17a-diol-3,20-dione 21-ACETOXY-4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETOXY-4-PREGNENE-11BETA,17ALPHA-DIOL-3,20-DIONE 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 4-PREGNEN-11BETA,17ALPHA,21-TETROL-3,20-DIONE 21-ACETATE 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE ACETIC ACID 2-((8S,9S,10R,11S,13S,14S,17R)-11,17-DIHYDROXY-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER CORTISOL 21-ACETATE CORTISOL ACETATE DELTA4-PREGNEN-11BETA,17ALPHA-21-TRIOL-3,20-DIONE-ACETATE HYDROCORTISONE 21-ACETATE HYDROCORTISONE ACETATE HYDROCORTISONI ACETAS HYDROCORTONE ACETATE LANACORT (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione |
| CAS NO | 50-03-3 |
| EINECS | 200-004-4 |
| Molecular Weight | 404.5 |
| Molecular Formula | C23H32O6 |
| Product Categories | Adrenal cortical hormone drugs; API; Intermediates & Fine Chemicals; Pharmaceuticals; Biochemistry; Hydroxyketosteroids; Steroids; Hormone Drugs; Steroid and Hormone; Veterinaries |
| Mol File | 50-03-3.mol |
Hydrocortisone acetate Chemical Properties | |
|---|---|
| Melting point | 223 °C (dec.)(lit.) |
| Boiling point | 446.1°C (rough estimate) |
| density | d420 1.289 |
| alpha | D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone) |
| refractive index | 1.4593 (estimate) |
| Fp | 223°C |
| storage temp | 0-6°C |
| solubility | Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride |
| Water Solubility | Insoluble in water. |
| Decomposition | 223 ºC |
| Merck | 14,4787 |
| BRN | 2066841 |
| Stability | Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 50-03-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydrocortisone acetate(50-03-3) |
| Safety Information | |
|---|---|
| Hazard Codes | Xn,T |
| Risk Statements | 63-10-45 |
| Safety Statements | 36/37-45-53 |
| WGK Germany | 3 |
| RTECS | GM8960000 |
| HS Code | 29372100 |
| Toxicity | LD50 intraperitoneal in mouse: 2300mg/kg |
| Hydrocortisone acetate Usage And Synthesis | |
|---|---|
| Adrenocorticotropic hormone drugs | Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone. Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added. |
| Indications | For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis. Figure 1 the chemical structure formula of tetra-fluoroethane. |
| Contraindications | Contraindications 1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited. |
| Adverse Reactions | Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection. |
| Precautions | 1. Not long-term, large-scale use. 2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication. |
| Chemical Property | White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether. |
| Uses | Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect. |
| Production methods | Hydrocortisone and acetic anhydride in pyridine esterification. |
| Chemical Properties | white powder |
| Uses | Glucocorticoid |
| Brand name | Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck). |
| Purification Methods | The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.] |
| Hydrocortisone acetate Preparation Products And Raw materials | |
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| Package method |
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FAQ
MOQ: 100 gram
Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.
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