Ethisterone - API Active Pharmaceutical Ingredient

Ethisterone

Name	Ethisterone
Synonyms	Prone Pranone Pregnin NSC-9565 Prolutol Prodoxan Produxan Colutoid Ethinone Gestoral Trosinon prolutonc Progestab Prodroxan primolutc Trosinone Ora-Lutin Lutocylol Nalutoral Lutocyclin Lutocyclol Primolut C Nugestoral Proluton C progestinp Progestoral Progestin P lutidonoral Aethisteron ETHISTERONE Lutidon Oral Progestolets Syngestrotabs lucorteumoral Ethisterone 0 Aethisteronum ETHISTERONE(P) Pregneninolone Lucorteum Oral Ethisterone,98% ETHISTERONE(RG) ETHYNYLTESTOSTERONE ETHINYL TESTOSTERONE ETHYNYLANDROSTENOLONE ANHYDROXYPROGESTERONE ETHISTERONE(RG)(CALL) 17-Ethinyltestosterone 17A-ETHYNYLTESTOSTERONE 17α-ethynyltestosterone Testosterone, 17-ethynyl- ANHYDROHYDROXYPROGESTERONE 4,17A-PREGNEN-17B-OL-20-YNE 17ALPHA-ETHYNYLTESTOSTERONE 17-alpha-ethinyltestosterone ETHISTERONE WHO(CRM STANDARD) ETHISTERONE EPE(CRM STANDARD) 17-Hydroxypregn-4-en-zoyn-3-one 17-Hydroxypregn-4-en-20-yn-3-one (17-alpha)-pregn-4-en-20-yn-3-on 4,17a-pregnen-17b-ol-20-yn-3-one 17a-Hydroxypregn-4-en-20-yn-3-one 17A-ETHYNYL-4-ANDROSTEN-17B-OL-3-ONE 17b-hydroxy-4,17a-pregnen-20-yn-3-one 4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE (17α)-17-hydroxy-pregn-4-en-20-yn-3-one 17a-ethynyl-17b-hydroxy-4-androsten-3-one 17-hydroxy-17-alpha-pregn-4-en-20-yn-3-on 17-Hydroxy-17-alpha-pregn-4-en-20-yn-3-one 17-Ethynyl-17beta-hydroxyandrost-4-en-3-one 17alpha-Pregn-4-en-20-yn-3-one, 17-hydroxy- 17BETA-HYDROXY-4,17ALPHA-PREGNEN-20-YN-3-ONE 4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE Androst-4-en-3-one, 17alpha-ethynyl-17-hydroxy- Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17alpha)- 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one 17-beta-Hydroxy-17-alpha-ethynyl-4-androsten-3-one 17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHY Ethisterone,17α-Ethynyltestosterone, 17β-Hydroxy-4,17α-pregnen-20-yn-3-one, 4,17α-Pregnen-17β-ol-20-yn-3-one (8R,9S,10R,13S,14S,17S)-17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
CAS NO	434-03-7
EINECS	207-096-5
Molecular Weight	312.45
Molecular Formula	C21H28O2
Product Categories	Steroids; Acetylenes; Biochemistry; Functionalized Acetylenes; Hydroxyketosteroids; Intermediates & Fine Chemicals; Metabolites & Impurities; Inhibitors; progestogen estrogen; Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals; Steroid and Hormone; Pharmaceuticals
Mol File	434-03-7.mol

Ethisterone Chemical Properties
density	1.0697 (rough estimate)
Boiling point	392.36°C (rough estimate)
form	neat
Melting point	263-269 °C(lit.)
alpha	D23 +23.8° (dioxane); D25 -32.0° (pyridine)
refractive index	33 ° (C=1, Pyridine)
storage temp	-20°C Freezer
pka	13.10±0.60(Predicted)
Water Solubility	soluble in chloroform, DMSO (0.05 mg/ml), acetone
Merck	14,3741
BRN	1889895
InChIKey	CHNXZKVNWQUJIB-CEGNMAFCSA-N
CAS DataBase Reference	434-03-7
NIST Chemistry Reference	Ethisterone(434-03-7)

Safety Information
Hazard Codes	Xn,T
Risk Statements	40-48-61
Safety Statements	22-24/25-45-53
RIDADR	UN 2811
WGK Germany	3
RTECS	TU5570250
HS Code	29372390

Ethisterone Usage And Synthesis
Chemical Properties	Off-White Powder
Originator	Lutocyclin,Ciba
Uses	Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Definition	ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process	0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function	Progestin

Ethisterone Usage And Synthesis
Chemical Properties	Off-White Powder
Originator	Lutocyclin,Ciba
Uses	Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Definition	ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process	0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function	Progestin

Package method

包装材料.jpg

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MOQ: 100 gram

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