17α-Hydroxyprogesterone - API Active Pharmaceutical Ingredient

17α-Hydroxyprogesterone

Name	17α-Hydroxyprogesterone
Synonyms	17A-HYDROXY-4-PREGNENE-3,20-DIONE 17a-hydroxypregn-4-ene-3,20-dione 17A-HYDROXYPROGESTERONE 17ALPHA-HYDROXY-4-PREGNENE-3,20-DIONE 17-ALPHA-HYDROXYPREGN-4-ENE-3,20-DIONE 17ALPHA-HYDROXYPROGESTERONE 17-HYDROXYPROGESTERONE 4-PREGNEN-17ALPHA-OL-3,20-DIONE 4-pregnen-17a-ol-3,20-dione 4-PREGNEN-17-OL-3,20-DIONE (8R,9S,10R,13S,14S,17R)-17-ACETYL-17-HYDROXY-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE HYDROXYPROGESTERONE HYDROXYPROGESTERONE, 17A- 17-Hydroxypregn-4-en-3,20-dione 17-hydroxy-pregn-4-ene-20-dione 17-hydroxypregn-4-ene-3,20-dione delta(4)-pregnene-17alpha-ol-3,20-dione gestagenogador prodix prodox
CAS NO	68-96-2
EINECS	210-062-2
Molecular Weight	330.46
Product Categories	steroids
Molecular Formula	C21H30O3
Mol File	604-09-1.mol
Melting point	212-215 °C
Boiling point	482.9±45.0 °C(Predicted)
density	1.15±0.1 g/cm3(Predicted)
pka	13.03±0.60(Predicted)
CAS DataBase Reference	604-09-1(CAS DataBase Reference)
NIST Chemistry Reference	17Alpha-hydroxy progesterone(604-09-1)

Safety Information
Hazard Codes	T,F
Risk Statements	61-39/23/24/25-23/24/25-11
Safety Statements	53-22-36/37/39-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	TU5060000
HS Code	38220090
Hazardous Substances Data	68-96-2(Hazardous Substances Data)

Hydroxyprogesterone Usage And Synthesis
Chemical Properties	White Solid
Originator	Prodox,Upjohn
Uses	Progesteron. It was isolated from adrenal glands
Uses	anticoagulant
Uses	17α-Hydroxy Progesterone is a metabolite of Progesterone. It was isolated from adrenal glands.
Definition	ChEBI: A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone
Indications	ogesterone. Indications Hydroxyprogesterone has been used prophylactically for the 12th to 37th week of pregnancy, particularly in women who are in the high-risk category for premature delivery (e.g., those with a history of premature delivery or spontaneous abortion). A concern relating to teratogenic potential has limited its use. Hydroxyprogesterone as a tocolytic agent requires further evaluation before its routine prophylactic administration can be recommended.
Manufacturing Process	A suspension of 90.0 g of δ5-pregnen-3β,17α-diol-20-one in 2300 ml of 85% formic acid was shaken for 2 h at a temperature of 70C. During this time the compound partially dissolved and at the same time a new crystalline substance appeared in the solution. After cooling, the precipitate was filtered, thus giving 80.0 g of the 3-formate of δ5-pregnen-3β,17α-diol-20-one having a melting point of 204°-207°C. 5.0 g of the 3-formate of δ5-pregnen-3β,17α-diol-20-one suspended in 120 ml of acetic anhydride was treated with 1.5 g of p-toluenesulfonic acid and the mixture was stirred for 9 h at room temperature. It was poured into water and after 2 h standing, the precipitate was filtered and washed to neutral, thus yielding the 3-formate 17-acetate of δ5-pregnen-3β,17α-diol-20-one in a yield of over 90%. 1.0 g of 3-formate 17-acetate of δ5-pregnen-3β,17α-diol-20-one was dissolved in 30 ml of xylene and 10 ml of cyclohexanone and 4 ml of the solution were distilled in order to remove traces of moisture. 1.0 g of aluminum isopropylate was added to the hot solution and the mixture was refluxed for 45 min. After cooling to 90°C, water was added and the organic solvents were removed by steam distiliation. Salt was added to the aqueous suspension and the residue was filtered, dried and extracted with hot acetone. The acetone solution was evaporated to dryness and the residue was crystallized from chloroformmethanol, thus giving 610.0 mg of the 17-acetate of δ4-pregnen-17α-ol-3,20- dione (17-acetoxy-progesterone) with a melting point of 239°-240°C. Saponification of this compound with 1% methanolic potassium hydroxide yielded 80% of δ4-pregnen-17α-ol-3,20-dione.
Therapeutic Function	Progestin

Hydroxyprogesterone Preparation Products And Raw materials
Raw materials	Diosgenin-->Formic acid-->Aluminium isopropoxide-->Potassium hydroxide-->Acetic anhydride-->p-Toluenesulfonic acid
Preparation Products	17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate-->Megestrol acetate-->3,20-Dioxopregn-4-en-17-beta-yl acetate-->6-Dibromomethylene-17-hydroxypregn-4-ene-3,20-dione 17-acetate

Package method

包装材料.jpg

FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.

Shipment: By express to buyers’ door. 100% make sure delivery.

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Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost.

CATALOG

Steroid/Hormone Raw Materials

Finsihed Steroid/Hormone/Peptides