Compared to the traditional protein pump inhibitor Lansoprazole, Vonoprazan takes effect through competitive and reversible inhibition of K+ in protein pumps. Clinical and animal experiments show that Vonoprazan acts faster than PPI or H2 receptor blockers, has a stronger pH raising effect, can swiftly alleviate gastric symptoms, allows enzyme recovery after dissociation, and has few side effects. Multiple clinical trials have proved that in cases of erosive esophagitis, Vonoprazan prevents and treats gastric and duodenal ulcers. As a first-line response for eradicating helicobacter pylori, it has shown significant efficacy, higher than Lansoprazole and with minimal side effects.
Vonoprazan has high lipophilicity and dissociation constant, so in acidic environments, it can take effect without the activation of acid. Vonoprazan’s inhibition of protein pumps does not require acid activation. Upon entering the stomach at a high concentration in its first dosage, it produces its strongest inhibiting effect, which can last for 24 hours. Vonoprazan is a stable acid, and it can rapidly increase the pH in the stomach and suppress gastric acid.
Vonoprazan has minimal influence on other enzyme and bodily functions, making it very safe and tolerable. Traditional PPIs are metabolized by CYP2C19, while Vonoprazan is not. Its efficacy and required dosage do not differ dramatically in different patients, making it an advantageous individualized drug regimen for patients.