Fluocinonide - API Active Pharmaceutical Ingredient

Fluocinonide

Name	Fluocinonide
Synonyms	Cortalar; Gelisyn; Lidemol; Fluocinonide (100 mg); Fluocinonide(Vanos); (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione; Flucetonide; Vanos
CAS NO	356-12-7
EINECS	206-597-6
Molecular Weight	494.52
Molecular Formula	C26H32F2O7
Product Categories	Steroids; LIDEX; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File	356-12-7.mol

Fluocinonide Chemical Properties
Melting point	309 °C
density	1.2001 (estimate)
Boiling point	235°C (rough estimate)
storage temp	Refrigerator
solubility	DMSO: ≥19mg/mL
form	powder
alpha	D +83° (chloroform)
pka	12.77±0.70(Predicted)
Water Solubility	0.53mg/L(25 ºC)
color	white to tan
optical activity	[α]/D +75 to +90°, c = 1 in dichloromethane
InChIKey	WJOHZNCJWYWUJD-IUGZLZTKSA-N

Fluocinonide Usage And Synthesis
Chemical Properties	White Solid
Originator	Topsyn ,Recordati,Italy,1970
Uses	Glucocorticoid; anti-inflammatory
Uses	Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Indications	Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Manufacturing Process	To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room temperature for 3 hours. During this period the crystals gradually dissolve and the clear solution is neutralized with dilute bicarbonate and the acetone removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95% alcohol to give the pure acetonide. A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine and 1 ml of acetic anhydride is allowed to stand at room temperature for 18 hours. Removal of the reagents in vacuo gives a crystalline residue which after crystallization from acetone-hexane gives the pure 16α,17α- isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described in US Patent 3,197,469.
Brand name	Lidex (Medicis); Vanos (Medicis).
Therapeutic Function	Antiinflammatory, Glucocorticoid

Fluocinonide Preparation Products And Raw materials
Raw materials	6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione-->PERCHLORIC ACID-->Acetone-->Acetic anhydride

Fluocinonide Preparation Products And Raw materials

Raw materials

6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione-->PERCHLORIC ACID-->Acetone-->Acetic anhydride

Package method

包装材料.jpg

FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.

Shipment: By express to buyers’ door. 100% make sure delivery.

Payment: TT/ Western Union/BTC/ETV/VISA and so on, please contact by email.

Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost.

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