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Cyproterone Acetate
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Cyproterone Acetate

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NameCyproterone Acetate
Synonymscyprosteroneacetate;
1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio;
1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat;
1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate;
17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio;
20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3;
6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4;
6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
SH-714
ANDROCUR
CYPROSTAT
nsc-81430
Cyproviron
Androcurone acetate
cyproteron-racetate
cyprosteroneacetate
CYPROTERONE ACETATE
CYPROFERONE ACETATE
CIPROTERONE ACETATE
Androcur, Cyprostat
CyproteroneAcetateEdmf
CyproteroneAcetateedmfep5
cyproterone17-alpha-acetate
* Color Pronk (cyproterone)
Cyproterone acetate(Androcur)
Cyproterone Acetate BP2000,EP2000
Cyproterone acetate for peak identification
6-Chloro-1α,2α-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
20-dione,6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-pregna-6-diene-3
6)-pregnadiene-17-alpha-ol-3,20-dione17-2-alpha-methylene-6-chloro-(sup4
6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
1,2-alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione17-alpha-acetate
6-chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesteroneacetate
6-chloro-delta(sup6)-1,2-alpha-methylene-17-alpha-hydroxyprogesteroneacetat
1,2-alpha-methylene-6-chloro-delta(sup6)-17-alpha-hydroxyprogesteroneacetat
6-chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup6)-progesteroneaceta
4,6-PREGNADIEN-6-CHLORO-1-ALPHA, 2-ALPHA-METHYLENE-17-OL-3,20-DIONE ACETATE
1,2-alpha-methylene-6-chloro-delta-(sup4,6)-pregnadiene-17-alpha-ol-3,20-dio
17-alpha-acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dio
6-chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dioneacet
6-Chloro-1β,2β-dihydro-17-hydroxy-3μH-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
(1β,2β)-17-(acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
6-CHLORO-1BETA,2BETA-DIHYDRO-17-HYDROXY-3'H-CYCLOPROPA[1,2]-PREGNA-1,4,6-TRIENE-3,20-DIONE ACETATE
6-chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
3H-Cyclopropa1,2pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)-
CAS NO427-51-0
EINECS207-048-3
Molecular Weight416.94
Molecular FormulaC24H29ClO4
Product CategoriesIntracellular receptor;
Antibiotics;
Steroids;
Intermediates & Fine Chemicals;
Pharmaceuticals;
Steroid and Hormone;
VETRANAL;
Hormone Drugs
Mol File427-51-0.mol





Cyproterone acetate Chemical Properties
Melting point200-201°C
Boiling point528.8°C (rough estimate)
density1.0677 (rough estimate)
storage temp2-8°C
refractive index1.4429 (estimate)
solubilityPractically insoluble in water, very soluble in methylene chloride, freely soluble in acetone, soluble in methanol, sparingly soluble in anhydrous ethanol.
formneat
λmax281nm(MeOH)(lit.)
Merck14,2774
EPA Substance Registry System3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- (427-51-0)




Safety Information
Hazard CodesXn,Xi
Risk Statements20/21/22-40-36/37/38
Safety Statements22-36-26
WGK Germany3
RTECSGZ2230000
HS Code29372900
Hazardous Substances Data427-51-0(Hazardous Substances Data)




Cyproterone acetate Usage And Synthesis
Chemical PropertiesCrystalline Solid
OriginatorAndrocur ,Schering,W. Germany,1973
UsesUsed as an antiandrogen. Combinded with estrogen in the treatment of acne
UsesThe free alcohol is an anti-androgen; cyproterone acetate is both an anti-androgen and a progestogen.
Combined with estrogen it is used in the treatment of acne.
Usesantiparasitic, fasciolicide
IndicationsCyproterone acetate is a progestational antiandrogen that blocks androgen receptor binding and suppresses androgen-sensitive tissues.
It is available in a topical form in Europe for the treatment of hirsutism.
Manufacturing Process2.34 g of 1,2α-methylene-δ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate are dissolved in 18.25 cc of ethylene chloride which contains 844 rng of perbenzoic acid.
The solution is stored for 16 hours at +5°C and 7 hours at room temperature.
It is then diluted with methylene chloride and, with aqueous ferrous sulfate solution, sodium bicarbonate solution and with water washed until neutral.
The organic phase is dried over sodium sulfate and then concentrated to dryness. 1.62 g of the thus obtained crude 1,2α-methylene-6,7α-oxido-δ4- pregnene-17α-ol-3,20-dione-17-acetate are dissolved in 109 cc of glacial acetic acid.
This solution is then saturated at room temperature with hydrogen chloride gas and stored for 20 hours, It is then diluted with methylene chloride and washed with water until neutral.
The organic phase is dried over sodium sulfate and then concentrated to dryness.
The thus obtained crude 6-chloro-1α-chloromethyl-δ4,6-pregnadiene17α-ol-3,20-dione-17-acetate is heated to boiling in 20 cc of collidine for 20 minutes under nitrogen.
After dilution with ether it is washed with 4 N hydrochloric acid and washed with water until neutral.
After drying over sodium sulfate and concentration to vacuum the remaining residue is subjected to chromatography over silica gel.
Using a benzene-ethyl acetate mixture (19:1) there is eluated 900 mg of 6-chloro-1,2α-methyleneδ4,6-pregnadiene-17α-ol-3,20-dione-17-acetate, which upon recrystallization from isopropyl ether melts at 200° to 201°C.
Therapeutic FunctionAntiandrogen




Cyproterone acetate Preparation Products And Raw materials
Raw materials



Acetic acid

 



Package method


包装材料.jpg


FAQ

MOQ: 100 gram

Pack material: Plastic bag + Shockproof film + shockproof envelope + Cartons.   

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Shipment time: Within three working days after payment. Usually need ten days to arrive buyers’ address. Resend if lost.

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