Nandrolone Phenylpropionate

Name	Nandrolone Phenylpropionate 17b-hydroxyestr-4-en-3-one 17-(3-phenylpropionate)
Synonyms	17b-hydroxyestr-4-en-3-one 17-(3-phenylpropionate) 19-NORTESTOSTERONE PHENYLPROPIONATE 4-ESTREN-17BETA-OL-3-ONE 17-PHENYLPROPIONATE 4-ESTREN-17-BETA-OL-3-ONE PHENYLPROPIONATE 4-ESTREN-17B-OL-3-ONE 17-PHENYLPROPIONATE NANDROLONE PHENPROPIONATE NANDROLONE PHENYLPROPIONATE NANDROLONI PHENYLPROPIONAS 17-(1-oxo-3-phenylpropoxy)estr-4-en-3-one 17-beta-hydroxyestr-4-en-3-one hydrocinnamate 17-beta-hydroxy-estr-4-en-3-onhydrocinnamate 17-beta-hydroxy-estr-4-ene-3-on3-phenylpropionate 17-beta-Hydroxy-estra-4-en-3-one, 17-phenylpropionate 17-beta-hydroxy-estra-4-en-3-one,17-phenylpropionate 17-beta-Phenylpropionyloxy-4-estren-3-one 17beta-Phenylpropionyloxy-4-estrene-3-one 17b-hydroxyestr-4-en-3-one3-phenylpropionate 17β-hydroxyestr-4-en-3-one3-phenylpropionate 19-Norandrostenolone phenylpropionate 19-Nortestosterone, hydrocinnamate
CAS NO	62-90-8
EINECS(EC#)	200-551-9
MDL Number	MFCD00198407
Molecular Weight	406.56
Molecular Formula	C27H34O3

Nandrolone phenylpropionate Chemical Properties
density	1.0140 (rough estimate)
Boiling point	487.61°C (rough estimate)
Melting point	85-87°C
alpha	D +58° (chloroform)
refractive index	1.5460 (estimate)
storage temp	Controlled Substance, -20?C Freezer
NIST Chemistry Reference	4-Androstene-17-beta-ol-3-one, 19-nor-delta-, phenylpropionate(62-90-8)
InChIKey	UBWXUGDQUBIEIZ-QNTYDACNSA-N
CAS DataBase Reference	62-90-8(CAS DataBase Reference)

Safety Information
Risk Statements	20/21/22-40
Safety Statements	23-36
Hazard Codes	Xn
RTECS	KG7995000
Toxicity	LD50 intraperitoneal in mouse: > 1gm/kg

Nandrolone phenylpropionate Usage And Synthesis
Common hormone	Nandrolone Phenylpropionate is a commonly used hormone for promoting the synthesis metabolism of protein. It is produced by the esterification reaction between 19-nor-testosterone and phenylpropionyl chloride. Its dosage type is oily injection through intramuscular injection for administration. It can promote the protein synthesis as well as the savings of calcium, phosphorus, and potassium for treating severe osteoporosis, premature children, growth retardation, dwarfism, and severe malnutrition; it can also be used for inoperable breast cancer, dysfunctional uterine bleeding, and uterine muscle aneurysm. However, this product has a slightly masculine role which is not suitable for not long-term use; patients of prostate cancer, hypertension and pregnant women is disabled; patients of heart, liver and kidney dysfunction should take with caution.
Properties	It is white or white crystalline powder with special smell. Its melting point is 95~99 °C and relative density is 1.14g/cm3, [α] D20 + 48~+ 51 °C (dioxane). It is soluble in alcohol, tea oil, slightly soluble in vegetable oil but almost insoluble in water.
Pharmacological effects	This anabolic effect of this product is 12 times as high as testosterone propionate but has a relative small androgenic which is only 1.5 times as high as the latter one. It can promote protein synthesis and inhibit protein gluconeogenesis, and can also promote the deposition of calcium and phosphorus and the growth of bone tissue growth. Its effect of intramuscular injection can be maintained for 1 to 2 weeks.
Pharmacokinetics	Metabolism: hormone is mainly excreted in the urine with most part existing in the form of conjugate. However, the hormones in feces are mainly excreted in its free from while the major metabolized product of Nandrolone Phenylpropionate and nor-androstenediol in the urine is mainly 19-nor-androsterone (19-NA).
Indications	In the field of dermatology, it is mainly applied as a adjuvant treatment method for treating the negative nitrogen balance caused by high dose of corticosteroids, while increasing the protein in food; it is also used for treating exfoliative dermatitis, pemphigus, dermatomyositis, scleroderma, and senile pruritus. In addition, it can also used for treating severe burns, malignant tumor before and after surgery, refractory fractures and severe osteoporosis, premature children, significant growth retardation, dwarfism, severe malnutrition, loss of appetite, diarrhea and other serious chronic wasting diseases. In the meantime of other treatments, the product can be administrated. It can also alleviate the symptoms of inoperable breast cancer. It is also suitable to be applied to functional uterine bleeding, and uterine fibroids.
Function and Application	It is kind of anabolic hormones whose major effects include promoting protein synthesis, inhibiting protein degradation, promoting muscle growth, promoting weight increase, further retaining water, sodium, calcium, and phosphorus. It is clinical mainly used for treating the cases of lack of enough protein synthesis and increased protein decomposition such as malnutrition, stunted children, severe burns, post-operative recovery period, refractory fractures, osteoporosis in the elderly and chronic wasting disease (such as chronic kidney disease, malignant tumor, hyperthyroidism and anemia); also used for treating the negative nitrogen balance caused by long-term frequent use of glucocorticoids. However, at the mean time of administration, it is also necessary to increase the protein content contained in the food. This product has a unique foul smell; it is almost insoluble in water but soluble in ethanol and fatty oil.
Side effects	It has slightly masculine effect. After women’s administration of it, some cases such as hirsutism, acne, thicker sound, clitoral hypertrophy, amenorrhea, or menstrual disorders can occur. In these cases, the administration of this drug should be discontinued immediately. Long-term use can cause jaundice and liver dysfunction, and may also cause edema due to sodium retention.
Drug Interactions	1. Using it in combination with oral anticoagulant drug can improve the efficacy of the latter one and increase the tendency of increased bleeding. 2. Anabolic steroids can reduce glucose tolerance; diabetic patients should pay attention to adjust the dose insulin or orally administrated amount of hypoglycemic medicine during the treatment. 3. Others are the same as methyltestosterone.
Precautions	1. Patients of liver disease, kidney disease, hypertension, prostate cancer, breast cancer and pregnant women should be disabled. 2. It should not be used in healthy children. 3. Patient of benign prostatic hypertrophy, myocardial infarction or with history of coronary artery disease should take with caution. 4. This product is prohibited as long-term nutritional products used in healthy people. 5. During the medication period, patients should increase the uptake of nutrition, especially protein. 6. It demands deep intramuscular injection.
Chemical Properties	White to Off-White Solid
Originator	Durabolin,Organon,US,1959
Uses	Anabolic steroid; androgen.
Manufacturing Process	An ice-cold solution of 1.5 grams of 19-nortestosterone and 1.5 ml of dry pyridine in 10 ml of dry benzene is prepared and a solution of 1.5 ml of β- phenylpropionyl chloride in 5 ml of dry benzene is added dropwise over a period of about 2 minutes with stirring. The resulting mixture is allowed to stand overnight under an atmosphere of nitrogen and then washed successively with cold 5% aqueous hydrochloric acid solution, cold 2.5% aqueous sodium hydroxide solution, and water. After drying over anhydrous sodium sulfate, the solvent is evaporated to give an almost colorless oil. Recrystallization from methanol gives white crystals of 19-nortestosterone 17- β-phenylpropionate, MP 91° to 92.5°C.
World Health Organization (WHO)	Nandrolone phenylpropionate, an anabolic steroid, was introduced in 1959. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone phenylpropionate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.
Brand name	Durabolin (Organon);Anabolicas;Anabolicus;Anabolin depot;Anabolin la-100;Androline;Androlone-d;Anticatabolin;Bexobolic;Deca-durabolin;Docabolin;Durabolin phenpropionate;Dynabalon;Energital;Fherbolico;Hepa-obaton;Hybolin decabiate;Hybolin improved;Kabolin;Keratyl;Kompleteron;Methybol-depot;Neo-durabolic;Nerobolin;Norabol;Noralone;Norandrol;Norandros;Noromon;Norstenol;Nortesto;Sintabolin;Stenabolin;Superbolin;Suprabolin
Therapeutic Function	Anabolic