Prednisolone Acetate

Name	PrednisoloneAcetate
Synonyms	11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE 1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE 1-DEHYDROCORTISOL 21-ACETATE 21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE DELTACORTENOLO HYDROCORTIDELT INFLANEFRAN METACORTANDROLONE ACETATE PREDNISOLONE 21-ACETATE PREDNISOLONE ACETATE PRICORTIN (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione 11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione
CAS NO	52-21-1
[EINECS(EC#)]	200-134-1
MDL Number	MFCD00037710
Molecular Weight	402.48
Molecular Formula	C23H30O6

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Prednisolone-21-acetate Chemical Properties
Melting point	240-244 °C
alpha	D25 +116° (dioxane)
density	1.28±0.1 g/cm3(Predicted)
Boiling poin	579.8±50.0 °C(Predicted)
storage temp	2-8°C
refractive index	112 ° (C=1, Dioxane)
form	neat
solubility	Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride.
Water Solubility	11.6mg/L(25 ºC)
BRN	3111798
Merck	7721
Stability	Stable. Incompatible with strong oxidizing agents.
NIST Chemistry Reference	1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1)
CAS DataBase Reference	52-21-1(CAS DataBase Reference)

Prednisolone-21-acetate Usage And Synthesis
Chemical Properties	White or almost white, crystalline powder.
Originator	Sterane, Phipharmex ,US ,1955
Uses	Synthetic corticosteroid; metabolically interconvertible with prednisone
Uses	glucocorticoid
Manufacturing Process	To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.
Brand name	Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer)
Therapeutic Function	Glucocorticoid
Purification Methods	Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]

Package method

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